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The CURLY Study

Cefalexin for UTIs – Right treatment Length in Young children.

A multi-centre, randomised trial to determine the optimal duration of cefalexin therapy for the treatment of febrile urinary tract infections in children.

CURLY Patient Information Animation

Please watch our animation to find out more about the CURLY study.


Urine infections (water infections) are very common in children. Around 1 in 10 girls and 1 in 30 boys will have had a urine infection by the age of 16 years. They can cause high temperatures, tummy pains and vomiting and can be distressing for children and parents.

Urine infections are often treated with a course of antibiotic medicine for 7 - 10 days. This would usually be with an antibiotic called cefalexin.

Doctors are not sure of how many days are needed for the medicine to work. In adults, just a few days of antibiotics is usually enough to treat the infection, but we are not sure if this is the same for children. Shorter courses of antibiotics may have several benefits over longer courses:

  1. Fewer side-effects, like diarrhoea and vomiting.
  2. A lower risk of developing 'bad bacteria', which don't respond to normal antibiotics.
  3. Children might start to feel better sooner.

Taking Part

Find out more about taking part in the study

About the Study

Learn more about the study

Contact Us

Get in touch with the study team

CURLY Trial study logo

Birmingham Clinical Trials Unit
Public Health Building
University of Birmingham
B15 2TT

[email protected]

0121 415 9125


The CURLY Study is funded by the National Institute for Health and Care Research (Award ID: NIHR134534). The views expressed are those of the authors and are not intended to be representative of the views of the funder, sponsor or other participating organisations.

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